Title

a. Right Nasal Cavity

b. Septoplasty

c. Left Nasal Cavity

d. Frontal Sinusotomy

1. Approach and Exposure

2. Nasoseptal Flap

3. Superior Septectomy

4. Expose Olfactory Bulb

a. Olfactory Bulb Resection

5. Dural Resection

6. Reconstruction

First described by Berger in 1924, esthesioneuroblastoma (ENB) remains a rare sinonasal tumor believed to originate from specialized sensory olfactory cells. To date, the literature includes 1,000 recorded cases of ENB. Patients with ENB often present with non-specific symptoms, most often chronic nasal obstruction or epistaxis. Careful examination may reveal a pink or brown polyploid mass in the nasal cavity. Overall, ENB may demonstrate various growth patterns ranging from slow, indolent progression to aggressive invasion with widespread metastasis.

Current literature indicates that ENB should be treated with a combination of surgical resection and postoperative radiation therapy with or without chemotherapy. However, significant controversy remains regarding the appropriate surgical approach. This video demonstrates a transnasal endoscopic approach, which has gained significant popularity over the previous two decades compared to classic “open” approaches. Although this approach demonstrates improved perioperative outcomes while still achieving oncologic margins, further work is required to evaluate long-term survival.

<h4>CHAPTER 1</h4><p>This is an endoscopic transcribiform approach for a small olfactory neuroblastomalimited to the right olfactory cleft.We start by looking into the right nasal cavityusing the zero-degree endoscope.And we see the prior biopsy site with Gelfoam,medial to the middle turbinate.We begin by medializing the middle turbinate.And we resect the middle turbinate using scissors.Once the middle turbinate is removed,the debrideris used to remove the remnants.And the vascular pedicle often needs to be cauterized.We then perform -removal of the uncinate process.This is followed by a maxillary antrostomy,and -total ethmoidectomy.The lamina papyracea needs to be fully exposed.Here, the sphenoid sinus ostium is identified and widened,and the Coblator is used to obtain hemostasis.</p><p>Here we're making the hemitransfixion incision on the left side.And the mucoperichondrial flap is raised from the left septum.Very, very limited septoplasty is performedin order to optimize exposure to the left nasal cavity.</p><p>We now visualize the left middle turbinate, -which is then resected.And maxillary antrostomy, total ethmoidectomy, and sphenoidotomyare also performed on this side.</p><p>Here, we are usingan angled endoscope with curved instrumentsto performleft frontal sinusotomyThis is also done on the right side.</p><h4>CHAPTER 2</h4><p>Here, we're using an extended-length needle tip bovie.To raise -a nasoseptal flap on the left side.Incisions are made superiorly -and inferiorly.The details of this will bediscussed in a separate video.The septal flap is then tucked away in the nasopharynx.</p><h4>CHAPTER 3</h4><p>Here on the right side, we're completing the cutsto perform a superior septectomy,which will allow a binostril approach to the anterior skull base.The Coblator is effectiveat attaining hemostasis along the anterior skull base.Now we can see the cribriform plate,lateral lamella, and fovea ethmoidalis on both sides.</p><h4>CHAPTER 4</h4><p>The remainder of the mucosa is removed,and a high-speed drill with a diamond burr is used tothin the bone of the anterior skull base.This is performed with the drill and the suctionwith an assistant holding the endoscope.The bone is then removed to expose the dura.Here, the Coblator is used to coagulate the left anterior ethmoid artery.The Kerrison rongeur can also be used to -remove bone -to expose the dura.Here, we are drilling the bone of the crista galli -as well as the planum sphenoidale posteriorly.The bone is removed back to the sphenoid sinuses.Here, we see bilateral frontal sinuses,which serve as the anterior limit of dissection.Our neurosurgery colleague then joins us.We are using the bipolar toobtain hemostasis.This is the right anterior ethmoid artery, which we are cauterizing.The bone is further removed laterally, along the right ethmoid groove.</p><h4>CHAPTER 5</h4><p>The dural cuts are now being made with an 11 blade as well as scissors.Here, the falx cerebri is being cut -in order to complete the dural resection.We are using a zero-degree endoscopewith the patient's head in a slightly-extended position.The cut along the falx cerebri is taken posteriorly -with care to protect the frontal lobes.</p><p>We can see the left olfactory bulb and the left olfactory nerve,inferior to the scissors.The olfactory bulbs are respected as well.</p><h4>CHAPTER 6</h4><p>Once the dura is resected,we then perform a skull base reconstructionusing a multi-layer technique.Some Surgicel has been placed -and we are now inlaying a collagen-based, dural graft.Here, the nasoseptal flap is retrieved from the nasopharynx -and positioned -over the anterior skull base defect.</p>

Watch this full-length, narrated surgical video of an endoscopic approach to an anterior skull base resection of an esthesioneuroblastoma performed at Duke University Medical Center.

Duke University Medical Center